|
KMID : 0371319930450060929
|
|
Journal of the Korean Surgical Society
1993 Volume.45 No. 6 p.929 ~ p.936
|
|
|
Cellular Immunity to Autologous Breast Cancer and the Effect of PSK(Copolang) on It
|
|
이수정
김춘직/김상운/심민철/권굉보/김동석
|
|
|
Abstract
|
|
|
The relationship between cell mediated immunity to autologous breast cancer tissue and subsequent clinical behavior has been studied since 1953. In an attempt to obtain information regarding specific cellular response to breast cancer. Black and
Leis
introduced the use of cryostat section of autologous breast cancer tissue as target in skin window test(SWT).
In order to determine the cell-mediated immunity and to examine the effect of polysaccharide-K(copolang(r)). which is nonspecific immumopotentiator, we performed SWT to autologous breast cancer tissue and Multitest(r) CMI in 31 patients with
breast
cancer at 1 month postoperatively and then 3 month adminstration of PSK. We also measured the nuclear grade of tissue and compared with the SWT and the effect of PSK.
The positive response rate of SWT were 41.9% and 61.3% at pre and posttreatment with PSK respectively, which showed the PSK increased the specific cellular to SWT (p<0.003) especially in stage II breast cancer. The positive reactivity decreased
in
frequency with advancing stage, i.e., node negative(50%) and node positive(33%).
The PSK was more effect in patients with negative response to SWT. The PSK enhanced the nonspecific cellular immunity because it increased the total number and total score of positive response to Multiest(r) CMI. Th PSK is more effective in
patients
with moderately differenciated nuclear grade. There findings provides that SWT is additional aid in imunotherapy and prognosis and follow up and may serve as a guide to the individula therapy.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|